211100-13-9

Name	Sabarubicin
CAS	211100-13-9
Molecular Formula	C32H37NO13
MDL Number	MFCD02101330
Molecular Weight	643.64
MOL File	211100-13-9.mol

Synonyms

Sabarubicin 5,12-Naphthacenedione, 7-[[4-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-, (7S,9S)- (7S,9S)-7-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione 5,12-Naphthacenedione, 7-((4-O-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)-2,6-dideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S,9S)-

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Chemical Properties

Boiling point	878.2±65.0 °C(Predicted)
density	1.59±0.1 g/cm3(Predicted)
pka	7.75±0.60(Predicted)

Hazard Information

Uses

Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations.

References

[1] Arcamone F, Animati F, Berettoni M, et al. Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo. J Natl Cancer Inst. 1997;89(16):1217-1223. DOI:10.1093/jnci/89.16.1217
[2] Mazzini S, Scaglioni L, Animati F, Mondelli R. Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755. Bioorg Med Chem. 2010;18(4):1497-1506. DOI:10.1016/j.bmc.2010.01.012

Supplier

JinOu Biomedical (Nanjing) Co., Ltd.

Telephone 13000000000

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1596079/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

PT CHEM GROUP LIMITED

Telephone+86-85511178; +86-85511178

Websitehttps://www.chemicalbook.com/manufacturer/henan-lihao-chem-plant-25020/

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