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N-Boc-N-bis(PEG4-acid) is a branched PEG linker with a Boc protected amino group and two terminal carboxylic acids. The protected amine can be deprotected under acidic conditions. Carboxylic acids can react with primary amino groups in the presence of EDC or HATU.

N-Boc-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005