204460-24-2

Name	NK-3201
CAS	204460-24-2
Molecular Formula	C31H29N5O6
MDL Number	MFCD03700768
Molecular Weight	567.59
MOL File	204460-24-2.mol

Synonyms

NK-3201 N-(3,4-dioxo-1-phenyl-7-pyridin-2-yloxyheptan-2-yl)-2-(5-formamido-6-oxo-2-phenylpyrimidin-1-yl)acetamide 1(6H)-Pyrimidineacetamide, N-[2,3-dioxo-1-(phenylmethyl)-6-(2-pyridinyloxy)hexyl]-5-(formylamino)-6-oxo-2-phenyl-

show less show more

Hazard Information

Description

NK3201 is a specific chymase inhibitor, which suppresses bleomycin-induced pulmonary fibrosis in hamsters.

Uses

NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein[1][2].

References

[1] Sakaguchi M, et al. A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters. Eur J Pharmacol. 2004 Jun 16;493(1-3):173-6. DOI:10.1016/j.ejphar.2004.04.024
[2] Takai S, et al. Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein. Life Sci. 2001 Aug 31;69(15):1725-32. DOI:10.1016/s0024-3205(01)01255-3

Supplier

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy