20348-16-7

General procedure for the synthesis of 2-amino-3-hydroxy-6-methylpyridine from 3-hydroxy-6-methyl-2-nitropyridine: 3-hydroxy-6-methyl-2-nitropyridine (30 g, 194.6 mmol) was dissolved in ethanol and the hydrogenation reaction was carried out for 1 hr at 50 °C using hydrogen (5 psi) and 20% Pd(OH)2/C catalyst. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 2-amino-3-hydroxy-6-methylpyridine as a brown solid (23.68 g, 98% yield). The NMR data of the product was consistent with the expected structure.

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