195981-08-9

Compared to untreated control mice, the number of apoptotic cells in tumors from mice treated with BMS-214662 increased. The Apoptotic Index (AI) in HCT-116 tumors from BMS-214662-treated mice increased by 4-10 times compared to the untreated control group. BMS-214662 exhibited significant cytotoxicity against HCT-116 and EJ-1 tumor cells; the doses of BMS-214662 required to kill 90% of clonogenic tumor cells were approximately 75 and 100 mg/kg for HCT-116 and EJ-1 tumors, respectively^[2].