ChemicalBook CAS DataBase List 2417987-45-0

2417987-45-0

Name	2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-
CAS	2417987-45-0
Molecular Formula	C29H32ClF4N7O2
Molecular Weight	622.06
MOL File	2417987-45-0.mol

Chemical Properties

Boiling point	743.4±70.0 °C(Predicted)
density	1.344±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: Soluble: =10 mg/ml Ethanol: Slightly soluble: 0.1-1 mg/ml
form	Solid
pka	9.13±0.40(Predicted)
color	White to light yellow

Hazard Information

Spectrum Detail

Supplier

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185

Websitehttp://www.caerulumpharma.com

Chunchuang (Wuhan) Technology Co., Ltd

Telephone 15727060112

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1427518/0_EN.htm

Chengdu DingDang Pharmaceutical Co., Ltd.

Telephone028-86040038 13980902949;

Websitehttp://www.dingdangchem.com

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Shanghai Chaolan Chemical Technology Center

Telephone021-QQ：65489617 15618227136

Websitehttp://www.atkchemical.com/

Chuzhou KeMail Chemical Technology Co., Ltd

Telephone0550-5196001 15000891977

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19947/0_EN.htm

Jiaxing Deyi Chemical Co., Ltd.

Telephone86-0573-85866609 13325730825

Websitehttps://www.chemicalbook.com/supplier/10156672/

Shanghai Yu Ben Biotechnology Co., Ltd.

Telephone 15502154572

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30592/0_EN.htm

Shanghai SPAR pharmaceutical technology co., LTD

Telephone021-000000 13917643586;

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30714/0_EN.htm

Shandong utilizing biological technology co., LTD

Telephone 15966937598

Websitehttp://www.hongtupharma.com/index.html

Shanghai Han-Xiang Chemical Co., Ltd.

Telephone 15971444841

Websitehttp://www.biochempartner.com.cn

Changzhou Yongfeng Biomedicine Co. Ltd.

Telephone 15006117673

Websitehttp://www.yongfengpharm.com

Zhejiang J&C Biological Technology Co.,Limited

Telephone+1-2135480471

Websitehttps://www.sarms4muscle.com

DC Chemicals

Telephone021-58447131 13564518121

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm

Changzhou Chenhong Biotechnology Co., Ltd.

Telephone+86-0519-85788828 +86-13775037613

Websitehttp://www.chemrenblock.com/

Jinan shenlikang chemical technology co. LTD

Telephone0531-86092839 13153040268

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1220925/0_EN.htm

Zhengzhou anmousse chemical products co. LTD

Telephone0371-55289822 18737195735

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList665224/0_EN.htm

Guangzhou Younan Technology Co., Ltd

Telephone020-82000279 18988968278

Websitehttp://www.ubiochem.cn/

1of4

Related Products

Send Inquriy

Animal Model:	Female C.B-17 SCID (Inbred) mice (20-21 weeks old; 24.1 g) with human NSCLC NCI-H2030.X1.1 cells^[1]
Dosage:	10, 25, or 100 mg/kg
Administration:	Oral gavage (PO) every day (QD) for 7 days (vehicle: 0.5% methylcellulose)
Result:	Decreased the ratio of free KRAS G12C to internal standard. Dose-dependent target engagement was observed for all time points (2, 8, and 24 h post-last dose), with over 90% KRAS G12C engagement observed for the highest dose 100 mg/kg assessed.

2417987-45-0

Chemical Properties

Hazard Information

Uses

in vivo

IC 50

storage

References

Spectrum Detail

Supplier

Related Products