ChemicalBook CAS DataBase List 19553-76-5

19553-76-5

Name	DISIALOGANGLIOSIDE GD1B 2NA
CAS	19553-76-5
Molecular Formula	C84H148N4O40
MDL Number	MFCD00466941
Molecular Weight	1854.08
MOL File	19553-76-5.mol

Chemical Properties

storage temp.	−20°C
solubility	Chloroform:Methanol:DI Water (2:1:0.1): soluble
form	lyophilized powder
InChIKey	AIUBMTQAHKTQMI-MPGPKOMUSA-N

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
Safety Statements	22-24/25 less more
WGK Germany	3
F	10-21
HS Code	29400090
Storage Class	11 - Combustible Solids

Hazard Information

Description

Ganglioside G_D1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside G_D1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside G_D1b levels are positively correlated with pilocytic astrocytoma tumor grade, and G_D1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. Ganglioside G_D1b mixture contains ganglioside G_D1b molecular species with C18:1 and C20:1 fatty acyl chains.

Uses

Ganglioside GD1b Disodium Salt (Bovine Brain) is a ganglioside, major constituents of neuronal cell membranes and endoplasmic reticulum that have been shown to modulate cell signal transduction.

General Description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

References

[1] L RIBONI. Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain.[J]. The Journal of Biological Chemistry, 1986, 261 18: 8514-8519.
[2] T. COMAS. Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors.[J]. Neuro-oncology, 1999, 1 4 1: 261-267. DOI: 10.1093/neuonc/1.4.261

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