ChemicalBook CAS DataBase List 191672-52-3

191672-52-3

Name	CS-003 Free base
CAS	191672-52-3
Molecular Formula	C34H38Cl2N2O6S
MDL Number	MFCD32197314
Molecular Weight	673.65
MOL File	191672-52-3.mol

Chemical Properties

Boiling point	846.5±65.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	8.69±0.20(Predicted)

Hazard Information

Biological Activity

CS-003 Free base (CS-003) is a tritachykinin receptor antagonist with high affinity for human neurokinin NK1, NK2 and NK3 receptors with Ki values of 2.3 nM and 0.54 nM, respectively and 0.74 nM.It can be used in the study of neurokinin-related respiratory diseases.

in vitro

CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively.

in vivo

CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID ₅₀ values of 0.13, 0.040 and 0.063 mg/kg, respectively.

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NK1

2.3 nM (Ki)

NK2

0.54 nM (Ki)

NK3

0.74 nM (Ki)