106128-89-6

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM). It less potently agonizes the NK1 receptor (EC50 = 35 μM) and is without effect on the NK2 receptor. Senktide is used to study the action of the NK3 receptor in cells and in animals.

Senktide is a selective Neurokinin NK3 tachykinin receptor agonist. Neurokinins (tachykinins) are members of a family of at least three neuropeptidessubstance Pneurokinin Aand neurokinin B (NKB)with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1NK2or NK3respectively. All three NK receptors are expressed in regions of the central nervous system th at are related to emotion and cognition (i.e.amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptorsincluding NK3 receptorsare also expressed in the motor and sensory systems of the digestive tract.''Senktide treatment in follicular phase goats enhances the liberation of luteinizing hormone (LH) and advance the time of ovulation. Senktide has the ability to suppress gonadotropin-releasing hormone (GnRH) transcription. Treatment with senktide stimulates c-Fos and imp

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