1852452-14-2

PF-739 is an AMPK agonist. It has been shown to activate AMPK in hepatocytes and skeletal muscle.

PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2].

AMPK α1β1γ1: 8.99 nM (EC₅₀); AMPK α1β2γ1: 126 nM (EC₅₀); AMPK α2β1γ1: 5.23 nM (EC₅₀); AMPK α2β2γ1: 42.2 nM (EC₅₀)

[1] Aledavood E, et al. Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739[J]. Frontiers in Molecular Biosciences, 2021, 8: 760026.
[2] Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25(5):1147-1159.e10. DOI:10.1016/j.cmet.2017.04.010