184025-19-2

Ciproxifan (1 mg/kg; a single p.o.) increases the t-MeHA level in mouse brain, with an ED₅₀ of 0.14 mg/kg^[1].
Ciproxifan (3 mg/kg, i.p.) improves the accuracy of responding in the five-choice task in rats only when the stimulus duration is 0.25 sec instead of 0.50 sec^[1].
Ciproxifan (0.15-2 mg/kg; p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats^[1].
Ciproxifan (1 mg/kg; a single i.v.) decreases the H₃-receptor ligand concentration in serum in mice, with the half-lives (t_1/2) of 13 and 87 min for the distribution and elimination phases in mice, respectively^[1].
Ciproxifan (1 mg/kg; a single p.o.) exhibits oral bioavailability (F=62%) and maximal concentration (C_max=420 nM) in mice^[1].