183485-32-7

IT-143A is a bacterial metabolite originally isolated from Streptomyces sp. IT-143. It is active against the bacterium M. luteus (MIC = 6.25 μg/ml) and the fungi A. fumigatus and T. rubrum in vitro (MICs = 12.5-25 μg/ml).

IT-143A is an antibiotic, that exhibits antibacterial and antifungal activity against Micrococcus luteus and Aspergillus fumigatus with MIC of 6.25-25 μg/mL. IT-143A inhibits growth of cancer cell KB with an IC50 of 0.36 ng/mL[1].

[1] Urakawa A, et al., IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp. J Antibiot (Tokyo). 1996 Oct;49(10):1052-5. DOI:10.7164/antibiotics.49.1052