865368-30-5

Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella.¹ It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm³, respectively).² Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm³, respectively).

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1. Lang, G., Blunt, J.W., Cummings, N.J., et al. Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp J. Nat. Prod. 68(8),1303-1305(2005).
2. Dahiya, R., Kumar, A., and Maheshwari, M. Toward the synthesis and biological evaluation of hirsutide Montash. Chem. 140(1),121-127(2009).