1807503-91-8

Name	2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane
CAS	1807503-91-8
Molecular Formula	C22H41NO8
MDL Number	MFCD28505566
Molecular Weight	447.56
MOL File	1807503-91-8.mol

Synonyms

AUN03918 C-NH-Boc-C-Bis-(C-PEG1-Boc) 2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane Propanoic acid, 3,3'-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1,3-propanediyl]bis(oxy)]bis-, 1,1'-bis(1,1-dimethylethyl) ester

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Hazard Information

Biological Activity

C-NH-Boc-C-Bis-(C-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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