145119-18-2

Name	Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester
CAS	145119-18-2
Molecular Formula	C14H27NO5
MDL Number	MFCD29764404
Molecular Weight	289.37
MOL File	145119-18-2.mol

Synonyms

Boc-NH-PEG1-C2-Boc N-Boc-PEG-t-butyl ester t-Butyl 3-(2-N-Boc-aminoethoxy)propanoate Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester

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Hazard Information

Biological Activity

N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Xi'an Confluore Biological Technology Co., Ltd.

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Shanghai Aizikang Pharmaceutical Research Co., Ltd

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Xian confluore Biological Technology Co., Ltd.

Telephone+86-15680926068 +86-15680926068

Websitehttp://www.confluore.com/

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