1802908-02-6

Methyltetrazine-PEG4-Maleimide is a click chemistry Maleimide linker. The maleimide group specifically and efficiently reacts with thiols to form thioether bond. This reagent can be used to efficieintly incorporate a tetrazine moiety with TCO-attached compound or macromolecule.

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005