1798871-31-4

Centrinone-B is a high affinity and selective PLK4 inhibitor. It depletes centriole and centrosome levels in vitro and induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

PLK4: 0.59 nM (Ki); PLK4 (G95L): 497.53 nM (Ki); Aurora A: 1239 nM (Ki); Aurora B: 5597.14 nM (Ki)

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