ATD-3169 is a ROS generator. ATD-3169 permeated mycobacteria to reliably enhance endogenous ROS including superoxide radicals. ATD-3169 was found to retain its potency in inhibiting a panel of multidrug resistant and extensively drug resistant Mtb strains.
Uses
ATD-3169 is an antibacterial agent. ATD-3169 enhances endogenous ROS, including superoxide radicals, to inhibit Mycobacterium tuberculosis (Mtb)[1].
References
[1] Tyagi P, et al. Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide. Free Radic Biol Med. 2015 Jul;84:344-354. DOI:10.1016/j.freeradbiomed.2015.03.008
