174838-38-1

5''-Deoxy-5''-methylthioadenosine-d₃ (MTA-d₃) is intended for use as an internal standard for the quantification of MTA by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (K_is = 0.15, 1.13, 13.9, and 0.68 μM for A₁, A_2A, A_2B, and A₃, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (K_i = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.

5''-(Methyl-d3-thio)adenosine (CAS# 174838-38-1) is a useful isotopically labeled research compound, where it is used in synthesis reactions.

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