174568-92-4

Glyoxalase I inhibitor free base (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research[1]. In Vitro:Glyoxalase I inhibitor free base (100 μM, 48 h) inhibits glyoxalase I, causes accumulation of methylglyoxal and leads to cytotoxicity in cells L1210 and B16 with GI50 of 3 μM and 11 μM[1].

4°C, protect from light, stored under nitrogen

[1] Kavarana MJ, et al., Mechanism-based competitive inhibitors of glyoxalase I: intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum. J Med Chem. 1999 Jan 28;42(2):221-8. DOI:10.1021/jm9708036