57449-30-6

COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 μg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model[1].

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[1] Takeuchi T, et al. A glyoxalase I inhibitor of a new structural type produced by Streptomyces. J Antibiot (Tokyo). 1975 Oct;28(10):737-42. DOI:10.7164/antibiotics.28.737