17176-77-1

3724-14-9

108-95-2

17176-77-1

Example 15 Synthesis of dibenzylphosphonate 15: Phenol 14 (0.51 g, 0.95 mmol) was dissolved in CH3CN (8 mL) and Cs2CO3 (0.77 g, 2.37 mmol) and trifluoromethanesulfonate (0.8 g, 1.90 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 1.5 h and then concentrated under reduced pressure to remove the solvent. The residue was subjected to liquid-liquid partitioning with EtOAc and saturated NaCl solution. The organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 3% MeOH/CH2Cl2) to afford dibenzylphosphonate 15 (0.62 g, 80% yield) as a white solid.