ChemicalBook CAS DataBase List 171714-84-4

171714-84-4

Name	Darusentan
CAS	171714-84-4
Molecular Formula	C22H22N2O6
Molecular Weight	410.42
MOL File	171714-84-4.mol

Chemical Properties

Boiling point	587.3±60.0 °C(Predicted)
density	1.268±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form	A solid
pka	1.82±0.10(Predicted)
color	White to off-white

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Hazard Information

Spectrum Detail

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Animal Model:	Twenty-four (eight per group) male Sprague Dawley rats weighing 175±200 g
Dosage:	30 mg/kg
Administration:	Administered orally in rat food for weeks 3 and 4
Result:	Reversed aortic alterations produced by infusion of Norepinephrine (2.5 μg/kg).