1643757-72-5

Name	Fosnetupitant chloride hydrochloride
CAS	1643757-72-5
Molecular Formula	C31H37Cl2F6N4O5P
Molecular Weight	761.52
MOL File	1643757-72-5.mol

Synonyms

Fosnetupitant hydrochloride Fosnetupitant chloride hydrochloride

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Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Uses

Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3?receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1].

in vivo

Fosnetupitant chloride monohydrochloride (i.v.) is converted in few minutes to Netupitant (HY-16346) invivo^[1].

IC 50

hNK1: 9.5 (pKi); hNK3: 6.1 (pKi)

References

[1] Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32. DOI:10.1016/j.peptides.2015.03.021

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