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4-Bromo-3-nitrobenzaldehyde is a benzaldehyde derivative, mainly used as an intermediate component in organic synthesis. It can be used to prepare 4-Bromo-3-chlorobenzoic acid and other benzoic acid compounds.

Step 1. Synthesis of 4-bromo-3-nitrobenzaldehyde: NaNO3 (5.48 g, 64.47 mmol, 1.19 eq.) was added to a 100 mL three-necked round-bottomed flask, followed by slow addition of 98% H2SO4 (60 mL). The reaction mixture was stirred continuously for 1.5 h at 10 °C. After that, 4-bromobenzaldehyde (10 g, 54.05 mmol, 1.00 eq.) was added to the reaction system and stirring was continued for 2 h at the same temperature. The reaction process was monitored by thin layer chromatography (TLC, unfolding agent ratio EtOAc:PE = 1:5). Upon completion of the reaction, 200 g of ice was added to the reaction mixture to quench the reaction. The resulting white solid product was collected by filtration and washed thoroughly with distilled water (3 x 200 mL) to yield 4-bromo-3-nitrobenzaldehyde (11.72 g, 94% yield).

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