1595278-21-9

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1].

Cell permeable: yes''Primary Target
NOD2''Reversible: yes''Target IC50: 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells

[1] Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1. DOI:10.1371/journal.pone.0069619