ChemicalBook CAS DataBase List 2757333-37-0

2757333-37-0

Name	[1,1'-Biphenyl]-4-butanoic acid, 4'-[(dipropylamino)sulfonyl]-
CAS	2757333-37-0
Molecular Formula	C22H29NO4S
Molecular Weight	403.54
MOL File	2757333-37-0.mol

Chemical Properties

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Animal Model:	LPS (HY-D1056) treated C57BL/6 mice ^[1]
Dosage:	200 mg/kg
Administration:	Intraperitoneal injection (i.p.); single dose
Result:	Significantly reduced levels of circulating inflammatory cytokines IL-1β, TNF-α and IFN-γ, while IL-10 was not affected.

Animal Model:	HKx31 (an IAV relative to PR8) treated C57BL/6 mice^[1]
Dosage:	20 mg/kg
Administration:	Nasal administration; 2-3 doses: days 1, 3 and 5 or days 3 and 5 post-IAV infection (day 0)
Result:	Reduced the weight loss and mortality of mice. Did not induce any noticeable pulmonary inflammation itself. Reduced IL-6, TNF-a and MCP-1 BALF concentrations. Reduced total cellular infiltrates in the lungs, characterised by significantly reduced neutrophils, macrophages and dendritic cells.