1532533-78-0

2-?[(1S)?-?1-?[4-?Amino-?3-?[3-?fluoro-?4-?(1-?methylethoxy)?phenyl]?-?1H-?pyrazolo[3,?4-?d]?pyrimidin-?1-?yl]?ethyl]?-?6-?fluoro-?3-?(3-?fluorophenyl)?-4H-?1-?benzopyran-?4-?one Hydrochloride (1:1) is a drug candidate. It is used in the preparation of 1H-Pyrazolo[3,4-d]pyrimidine derivatives as selective PI3K delta inhibitors for treatment of autoimmune and inflammatory disorders, and proliferative diseases such as cancer.

PI3Kδ: 22.2 nM (EC₅₀); PI3Kδ: 6.2 nM (Kd); PI3Kγ: 1400 nM (Kd); PI3Kβ: >10000 nM (Kd); PI3Kα: >10000 nM (Kd)

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