1513857-77-6

Hazard Information

Questions And Answer

• Binding Mode

  Pemigatinib binds to the inactive conformation of FGFR1 with the activation loop adopting a DFG-in conformation (type I1/2 inhibitor). The pyrrolopyridine moiety forms two hydrogen bonds with the NH and the carbonyl of Ala564 in the hinge region (Figs. 3, 4). The difluoromethoxyphenyl ring, which is perpendicular relative to the tricyclic ring, fits the specificity pocket containing the gatekeeper residue Val561. One of the methoxy oxygen atoms hydrogen bonds to the backbone NH of Asp641. The terminal morpholine extends towards the solventfront region, and makes only minor contacts with the protein.
  ;

Spectrum Detail

Supplier