149537-49-5

BPH-651 is a CrtM inhibitor.

BPH-651 is a compound with antibacterial activity and has the activity to inhibit dehydrosqualene synthase. BPH-651 can bind to different sites of dehydrosqualene synthase, providing structural clues for the mechanism and inhibition of head-to-head prenyltransferase, which will help future compound design.

[1] Head-to-head prenyl tranferases: anti-infective drug targets DOI:10.1021/jm300208p