148256-82-0

General procedure for the synthesis of 4-chloro-2-(methylthio)pyrimidine-5-carbaldehyde from (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol: Activated manganese(IV) oxide (38.1 g, 439 mmol, 5 μm) was added to (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol (16.73 g, 87.8 mmol) in a chloroform ( 800 mL) solution. The reaction mixture was stirred overnight at room temperature and after completion of the reaction, it was filtered through a pad of diatomaceous earth to remove solid impurities. The filtrate was concentrated under reduced pressure to afford 4-chloro-2-(methylthio)pyrimidine-5-carbaldehyde (13.7 g, 82.8% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 10.31 (s, 1H), 8.88 (s, 1H), 2.65 (s, 3H) ppm.

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