1451042-18-4

HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 μM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].

HDAC3: 0.24 μM (IC₅₀); HDAC1: 19 μM (IC₅₀); HDAC4: >100 μM (IC₅₀); HDAC6: >100 μM (IC₅₀); HDAC8: >100 μM (IC₅₀)

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[1] Suzuki T, et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669. DOI:10.1371/journal.pone.0068669