ChemicalBook CAS DataBase List 143703-25-7

143703-25-7

Name	CE3F4
CAS	143703-25-7
Molecular Formula	C11H10Br2FNO
Molecular Weight	351.01
MOL File	143703-25-7.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO > 10 mM
form	Powder
color	White to off-white
InChI	InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3
InChIKey	ZZLQPWXVZCPUGC-UHFFFAOYSA-N
SMILES	N1(C=O)C2=C(C(Br)=C(F)C(Br)=C2)CCC1C

Safety Data

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H411
Precautionary statements	P264-P270-P301+P312-P330-P501
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Aquatic Chronic 2

Hazard Information

Uses

CE3F4 has been used as a selective exchange protein directly activated by cAMP isoform 1 (Epac1) inhibitor in cell proliferation assay to study the influence of Epac type I on cell proliferation of C6 cells (a model of glioma).

Biological Activity

CE3F4 is a tetrahydroquinoline derivative th at blocks agonist-stimulated Epac1 (exchange protein directly activated by cAMP isoform 1) guanine nucleotide exchange activity toward its effector Rap1 (IC50 = 23 μM; Epac agonist = 2 μM 8-CPT-2μ-O-Me-cAMP) by targeting agonist-bound Epac1 in an agonist-uncompetitive manner without affecting the GDP exchange on Rap1Rap1-Epac1 interactionor PKA type I/II activity (CβRIβ & CαRIIβ). CE3F4 (20 μM) effectively inhbits cellular Rap1 activation upon 10 μM Sp-8-pCPT-2μ-O-Me-cAMPS (Epac1-transfected HEK293 and r at neonatal cardiac myocytes) or 10 μM β-adrenergic receptor agonist isoprenaline stimulation (β1AR & Epac1 dually transfected HEK293). The isolated CE3F4 R enantiomer is reported to display 10-fold Epac1 selectivity over Epac2and is 10-times more potent than the CE3F S enantiomer against Epac1.''Epac1 is a downstream effector of the cyclic adenosine monophosp

in vivo

CE3F4 (1-3 mg/kg; through a catheter in the internal jugular vein) inhibits atrial fibrillation (AF) and CE3F4 (3 mg/kg; i.v.) inhibits ventricular arrhythmias^[4].
CE3F4 (10 mg/kg; i.v.) improves cardiac function after myocardial infarction in mice^[5].

Animal Model:	Wild-type (WT) mice (induced AF after 20min of CE3F4 administration)^[4]
Dosage:	3 mg/kg and 1mg/kg
Administration:	Through a catheter in the internal jugular vein
Result:	Shortened the duration of the pacing-induced AF at 3mg/kg.

Animal Model:	Casq2-KO mice (premature ventricular contraction induced by isoproterenol injection 20min after CE3F4 administration)^[4]
Dosage:	3 mg/kg
Administration:	I.v.
Result:	Reduced the incidence of sympathetic activation-induced ventricular arrhythmias.

storage

Store at -20°C

Spectrum Detail

Supplier

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 18916372613

Websitehttps://www.shyuanye.com

ShangHai Biochempartner Co.,Ltd

Telephone177-54423994 17754423994

Websitehttps://www.biochempartner.com

Nanjing LuoDa Chemical Co., Ltd

Telephone025-66016961 13382082786;

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList20138/0_EN.htm

Career Henan Chemica Co

Telephone+86-0371-86658258 +86-13203830695

Websitehttps://www.coreychem.com/

Changzhou Chenhong Biotechnology Co., Ltd.

Telephone+86-0519-85788828 +86-13775037613

Websitehttp://www.chemrenblock.com/

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Telephone 15317229551

Websitehttps://www.ureiko.com

ShangHai ChuanQian Chemcial Technique Centre

Telephone 15869524721

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList68594/0_EN.htm

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

cjbscvictory

Telephone13348960310 13348960310

Websitehttps://www.weikeqi-biotech.com/

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

amyjet

Telephone4006800868;027-59626688 18771149750

Websitehttp://www.amyjet.com/

Wuhan Augda Biotechnology Co., Ltd

Telephone 15071299552

Websitehttps://www.chemicalbook.com/supplier/24275232/1.htm

Kaifeng Mingren Pharmaceutical Co.,LTD

Telephone0371-65741762

Websitehttps://www.kfmryy.com/

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Telephone+86-027-59232304 15387063101

Websitehttps://www.yingnor.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

1of4

Related Products

Send Inquriy