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CAY10679 is an anionic oligopeptide-based bola-amphiphile that contains a hexane moiety flanked by a glycylglycine group at each end, which creates distinct hydrophilic and hydrophobic regions.¹ The microtube self-assembling properties of this amphiphilic peptide have been studied in aqueous acidic solution.² Bola-amphiphiles are of interest in the construction of nanotubes, nanovesicles, nanowires, nanocarriers for drug delivery, and other applications of bionanotechnology.¹

N,N'-suberoyldiglycylglycine is a model bolaamphiphile (bola-shaped amphiphilic molecule) made up of two glycylglycine units linked by a suberic acid connecting group[1].

1. Santoso, S.S., Vauthey, S., and Zhang, S. Structures, function and applications of amphiphilic peptides Curr. Opin. Colloid In. 7,262-266(2013).
2. Naidoo, V.B., and Rautenbach, M. Bidirectional solid phase synthesis of a model oligoglycine bolaamphiphile and purification by rapid self-assembly J. Pept. Sci. 18(5),317-325(2012).