1356905-39-9

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Labeled Lisinopril, an orally active angiotensin-converting enzyme (ACE) inhibitor

Labelled Lisinopril, intended for use as an internal standard for the quantification of Lisinopril by GC- or LC-mass spectrometry

Lisinopril-d₅ is intended for use as an internal standard for the quantification of lisinopril by GC- or LC-MS. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 1.2 nM). It reduces the formation of endothelin-1 and increases nitric oxide in human vascular endothelial cells. Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID₅₀s = 2.3 and 6.5 μg/kg in rat and dog, respectively).

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[1] A. A. PATCHETT. A new class of angiotensin-converting enzyme inhibitors[J]. Nature, 1980, 288 5788: 280-283. DOI: 10.1038/288280a0
[2] GIOVAMBATTISTA DESIDERI. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway.[J]. Mediators of Inflammation, 2008, 2008: 305087. DOI: 10.1155/2008/305087