[2H5]-Quinapril
Quinapril D5Q: What is
Quinapril D5 Q: What is the CAS Number of
Quinapril D5 Q: What is the storage condition of
Quinapril D5 Q: What are the applications of
Quinapril D5
Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat.1,2 In vivo, quinapril (3 mg/kg) reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats.2 It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (10-200 mg/kg) prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.
storage
-20°C
References
1.Vago, T., Bevilacqua, M., Conci, F., et al.Angiotensin converting enzyme binding sites in human heart and lung: Comparison with rat tissuesBr. J. Pharmacol.107(3)821-825(1992)
2.Kaplan, H.R., Taylor, D.G., and Olson, S.C.Quinapril: Overview of preclinical dataClin. Cardiol.13(6 Suppl. 7)VII6-VII12(1990)
