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• Synthesis

  In a dry 100 mL reaction flask, under nitrogen protection, (1-methyl-1H-1,2,4-triazol-3-yl)methanol (0.25 g, 2.2 mmol) was dissolved in 10 mL of thionyl chloride. The resulting reaction mixture was heated to reflux and stirred for 2 hours while maintaining reflux. After the reaction was complete, the resulting reaction mixture was cooled to room temperature and then concentrated to dryness under vacuum (toluene can be added to the reaction mixture for further concentration to remove residual thionyl chloride). The resulting white solid (0.2 g) is the target product 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride, which requires no further purification. Synthetic route of 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride" alt="Synthetic route of 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride">

  Figure 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

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