ChemicalBook CAS DataBase List 1346133-08-1

1346133-08-1

Name	LY-2795050
CAS	1346133-08-1
Molecular Formula	C23H22ClN3O2
Molecular Weight	407.89
MOL File	1346133-08-1.mol

Chemical Properties

Boiling point	532.4±50.0 °C(Predicted)
density	1.287±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (122.58 mM; Need ultrasonic)
form	Powder
pka	15.57±0.50(Predicted)
color	White to off-white

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Animal Model:	C57BL/6J mice^[2] (gonadally intact, adult, male and female)
Dosage:	0.032-0.1 mg/kg
Administration:	i.p., 0.032-0.1mg/kg, 30 min
Result:	Could dose-dependently prevent the self-grooming deficits caused by U50,488 with a 30-min pre-treatment. Not effected in blocking the effects of U50,488 with smaller dose (0.032mg/kg) in either males or females. Decreased immobility in the FST in males at a dose of 0.1mg/kg, but not in females, up to a dose of 0.32mg/kg. Prevented and also reversed (at 0.32mg/kg) the locomotor-depressant effects of U50,488 (10mg/kg), in males and females.

1346133-08-1

Chemical Properties

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in vivo

References

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