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RCS-4 is a synthetic cannabinoid (CB) that has been detected as an adulterant of herbal mixtures. RCS-4 2-methoxy isomer is an analog of RCS-4 that differs only in the location of the methoxy group on the phenyl ring. The affinity of RCS-4 2-methoxy isomer for CB receptors, or its physiological effects, have not been documented. However, RCS-4 2-methoxy isomer structurally resembles JWH 250 , a cannabimimetic indole that shows a high-affinity for both CB₁ and CB₂ (K_i = 11 and 33 nM, respectively).

RCS-4 is a synthetic cannabinoid (CB) that has been detected as an adulterant of herbal mixtures. RCS-4 2-methoxy isomer is an analog of RCS-4 that differs only in the location of the methoxy group on the phenyl ring. The affinity of RCS-4 2-methoxy isomer for CB receptors, or its physiological effects, have not been documented. However, RCS-4 2-methoxy isomer structurally resembles JWH 250 , a cannabimimetic indole that shows a high-affinity for both CB1 and CB2 (Ki = 11 and 33 nM, respectively).[Cayman Chemical]

[1] RURI KIKURA-HANAJIRI  Yukihiro G  Nahoko Uchiyama. Survey of current trends in the abuse of psychotropic substances and plants in Japan[J]. Legal Medicine, 2011, 13 3: Pages 109-115. DOI: 10.1016/j.legalmed.2011.02.003
[2] JOHN W. HUFFMAN . 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 18: Pages 4110-4113. DOI: 10.1016/j.bmcl.2005.06.008