Uses
CHOLINE CITRATE is used in chemical reagents, organic intermediates, fine chemicals, pharmaceutical research and development.
Manufacturing Process
As described in US Patent 2,575,611, 107 parts of freshly prepared ferric
hydroxide are added to 295 parts of choline dihydrogen citrate dissolved in
200 parts of distilled water and heated to approximately 80°C until a
homogeneous solution occurs. The resulting reddish brown solution may be
used as such or it may be dried by evaporating the water. The dried product is
a reddish brown, amorphous solid presenting a glistening surface upon
fracture. The dry product is somewhat hygroscopic and is freely soluble in
water to give a stable solution. The following paragraph gives an alternative
preparation.
One mol of tricholine citrate is dissolved in 6,000 ml of water and two mols of
ferric citrate in solid form are added thereto. The reaction mass is then
agitated until solution is effected, and until the reaction mass changes from
brown to green. Water is removed either under vacuum, or as an azeotrope
with benzene or toluene or by heating to a temperature of 110° to 115°C.
There is thus obtained a gummy viscous mass which is treated with methanol,
about five gallons, whereupon it solidifies, i.e., changes, into a green
crystalline compound. Following the treatment with methanol, the mass is
filtered and the green compound dried at about 70°C, according to US Patent
2,865,938.
