1334177-84-2

Hydroxy-PEG8-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Hydroxy-PEG8-t-butyl ester (also known as Hydroxy-PEG8-Boc, Hydroxy-PEG8-Boc, HO-PEG8-CH2CH2COO-tBu and OH-PEG8-TBA, etc.; CAS 1334177-84-2) is a high-purity, monodisperse PEG cross-linking agent featuring terminal hydroxyl (-OH) groups and tert-butyl-protected carboxyl groups. This compound is widely used in the development of PROTACs and antibody-drug conjugates (ADCs) to enhance water solubility, improve biocompatibility, and facilitate sequential biocoupling.

PEGs