1333154-77-0

Azido-dPEG₇-amine is a heterobifunctional PEGylated linker. It contains a reactive NH₂ end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG₇-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.

Azido-PEG7-amine is used in methods for detecting assay interferences and increasing dynamic range.

reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry

Non-cleavable Linker; PEGs

[1] GOSWAMI L N, HOUSTON Z H, SARMA S J, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery?[J]. Organic & Biomolecular Chemistry, 2012, 7: 1116-1126. DOI: 10.1039/c2ob26968f
[2] VANESSA S. RODRIK-OUTMEZGUINE. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor[J]. Nature, 2016, 534 7606: 272-276. DOI: 10.1038/nature17963