1257063-35-6

Azido-PEG4-acid is a very popular PEG reagent containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Light yellow to colorless thick liquid

Azido-PEG4-Acid is amine- or phosphine-reactive building block used to derivative primary amines for ligation to alkyne-tagged molecules.

reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry

Tert-butyl 15-azido-4,7,10,13-tetraoxopentadecanoate (0.22 g; 0.63 mmol) was dissolved in pure DCM (5 mL) and TFA (5 mL) was added. The solution was stirred at room temperature for 1.5 hours. Next, the volatile compounds were removed in vacuo, the residue