13220-46-7

23876-18-8

13220-46-7

General procedure for the synthesis of 4-methylindolone from 2-(2-methyl-6-nitrophenyl)acetic acid: 2-(2-methyl-6-nitrophenyl)acetic acid (1.4 g, 7 mmol) was dissolved in 20 mL of methanol, 0.14 g of 10% palladium/carbon catalyst was added, and the reaction was placed in a Parr oscillator and hydrogenated for 3 hours at 60 psi hydrogen pressure. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation to remove the solvent. The brown solid obtained was ground with ethyl acetate and dried under vacuum to yield 0.9 g (74% yield) of 4-methylindolone as a white solid.