1276105-89-5

CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.

CNX-1351 inhibits p-Akt ^Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).

PI3Kα 6.8 nM (IC 50 )

PI3Kβ 166 nM (IC 50 )

PI3Kδ 240.3 nM (IC 50 )

PI3Kγ 3020 nM ( IC 50 )

Store at -20°C