ChemicalBook CAS DataBase List 12650-88-3

12650-88-3

Name	Lysozyme
CAS	12650-88-3
EINECS(EC#)	235-747-3
Molecular Formula	C15H20O4
MDL Number	MFCD00131557
Molecular Weight	2899.27
MOL File	12650-88-3.mol

Chemical Properties

vapor pressure	0Pa at 25℃
storage temp.	2-8°C
form	powder
color	white
PH	pH(15g/l, 25℃) : 3.0～5.0
biological source	chicken egg white
Water Solubility	Soluble in water at 10mg/ml.
Specific Activity	8000-120000U/mg
Absorption	3.9 at 280nm (10 mg enzyme/ml)

Safety Data

Hazard Codes	B
Safety Statements	23-24/25-22 less more
WGK Germany	3
RTECS	OL5989850
F	3-10
HS Code	35079090
Toxicity	mouse,LD50,intraperitoneal,5800mg/kg (5800mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSIONBEHAVIORAL: ATAXIA,Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 587, 1981. less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Lysozyme (muramidase) hydrolyzes preferentially the beta-1,4 glucosidic linkages between N-acetylmuramic acid and N-acetylglucosamine which occur in the mucopeptide cell wall structure of certain microorganisms, such as Micrococcus lysodeikticus. A somewhat more limited activity is exhibited towards chitin oligomers. Lysozyme is of widespread distribution in animals and plants. That which has been most extensively studied is from hen egg white (lysozyme C). Lysozyme is also found in mammalian secretions and tissues, saliva, tears, milk, cervical mucus, leukocytes, kidneys, etc. Lysozyme is inhibited by surface-active reagents such as dodecyl sulfate, alcohols and fatty acids. Imidazole and indole derivatives are inhibitors via formation of change-transfer complexes. Useful for the rapid isolation of RNA from gram negative bacteria. Can be used to prepare small amounts of plasmid DNA.

Uses

Catalyzes the hydrolysis of peptidoglycans found in bacterial cell walls. Lysozyme catalyzes is utilized for the hydrolysis of peptidoglycans found in bacterial cell walls. It is used as a precursor in the production of spheroplasts. It is also used as a preservative against many food spoiling microorganisms. It is used in skin care in order to cure and prevent acne and bed sores, dental and oral conditions. It is used for lysing E. coli and Streptomycetes for extraction purposes such as extracting group specific antigen. Further, it is used in non-pasteurized beer.

Application

Lysozyme from chicken egg white has been used for the extraction of genomic DNA from bacterial cells.It has been used as an external standard for MALDI-TOF (matrix assisted laser desorption ionization-time of flight) mass analysis.
Enzyme breaks down the cell walls of bacteria; used to prepare spheroplasts.

General Description

Lysozyme from chicken egg white, is a protein that can show broad spectrum of antibacterial activity against gram positive and gram negative bacteria. Its antimicrobial activity can be enhanced by pretreatment of the target microbial cells with chelating agents like ethylenediaminetetraacetic acid (EDTA).

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Lysozyme hydrolyzes β(1→4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. Gram-positive cells are quite susceptible to this hydrolysis as their cell walls have a high proportion of peptidoglycan. Gram-negative bacteria are less susceptible due to the presence of an outer membrane and a lower proportion of peptidoglycan. However, these cells may be hydrolyzed in the presence of EDTA that chelates metal ions in the outer bacterial membrane.The enzyme is active over a broad pH range (6.0 to 9.0). At pH 6.2, maximal activity is observed over a wider range of ionic strengths (0.02 to 0.100 M) than at pH 9.2 (0.01 to 0.06 M).

Material Safety Data Sheet(MSDS)

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12650-88-3

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Preparation Products

Hazard Information

Chemical Properties

Uses

Application

General Description

Flammability and Explosibility

Biochem/physiol Actions

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

References

Supplier

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