124190-19-8

FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. The mitogen-induced lymphocyte proliferation which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-901235.

FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice[1].

[1] T Shibata, et al. A new immunomodulator, FR-901235. J Antibiot (Tokyo). 1989 Sep;42(9):1356-61. DOI:10.7164/antibiotics.42.1356