1241675-76-2

Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3αβ(IC50= 4.1μM). Also shown to inhibit amyloid-βproduction in N2A-APP695cells.

(R)-DRF053 DiHydrochloride (cas# 1241675-76-2) is a useful research chemical.(R)-DRF053 Dihydrochloride was used for studying cancer treatments using combinations of CDK kinase and ERK inhibitors.

Store at -20°C