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Cefiderocol, is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, that has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species,

reagent type: chelator

Cefiderocol can be used for the treatment of complicated urinary tract infections (cUTIs) when other treatment options are limited or nonexistent.

Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wallleading to cell lysis and bacterial death.

Antimicrobial Spectrum: Cefiderocol has strong antimicrobial propertiesespecially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelatorwhich adds to its antibacterial activities.

Below shows the synthesis route of Cefiderocol

β-lactam