1214468-35-5

SIRT6-IN-1 is a novel SIRT6 inhibitor, with potential uses in treating in diabetes, immune-mediated disorders, and cancer.

SIRT6-IN-1 (2,4-dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide) is a cell penetrantpotent and selective inhibitor of SIRT6 (Sirtuin 6). It improves glucose tolerance in a type 2 diabetes mouse model. SIRT6-IN-1 delays experimental autoimmune encephalomyelitis disease onset in mice.